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KMID : 0545120060160111747
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Journal of Microbiology and Biotechnology
2006 Volume.16 No. 11 p.1747 ~ p.1752
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Fractions of Chamaecyparis obtusa Display Antiallergic Effect in RBL2H3 Cells
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Choi In-Gyu
Kim Kyung-Jong
Kim Young-Mi
Park Mi-Jin
Lee Yun-Sil
Jeoung Doo-Il
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Abstract
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Allergic inflammation results from stimulation of -hexosaminidase secretion, increased calcium influx, and activation of MAPK pathways. Some fractions of Chamaecyparis obtusa decreased secretion of -hexosaminidase, calcium influx, ROS, and phosphorylation of ERK. These results suggest that Chamaecyparis obtusa would be valuable for development of allergy therapeutics.
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KEYWORD
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Allergic inflammation, β-hexosaminidase, calcium influx, Chamaecyparis obtusa, ERK, reactive oxygen species
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